Neuroprognostication After Cardiac Arrest Using Glial Fibrillary Acidic Protein: A Systematic Review and Meta-Analysis
GFAP demonstrates time-dependent prognostic utility in predicting poor neurologic outcomes after cardiac arrest in adults, with optimal performance at 48-72 hours post-ROSC. These findings support suggest that GFAP shows potential as a time-dependent biomarker but remains investigational. Further prospective studies are needed to validate its clinical utility and to determine standardized cutoff values before routine implementation.
Authors
- Dimitrios Chatzis (ORCID: https://orcid.org/0000-0003-1610-3736)
- Georgios Mavrovounis (ORCID: https://orcid.org/0000-0001-7595-5598)
- Eleftherios Beltsios (ORCID: https://orcid.org/0000-0001-6193-2109)
- Ioannis Boutsikos (ORCID: https://orcid.org/0000-0002-1174-6268)
- Themis Gkraikou
- Antonis Adamou
- Theodosis Kalamatianos
- Maria Mermiri
- Ioannis Pantazopoulos
- Paraskevi Papageorgiou
Institutions
- University of Thessaly (GR)
- National and Kapodistrian University of Athens (GR)
- European University Cyprus (CY)
- Aristotle University of Thessaloniki (GR)
- Agios Pavlos General Hospital (GR)
- University of Cyprus (CY)
- Medizinische Hochschule Hannover (DE)
- University of West Attica (GR)
- Alexandra Hospital (GR)
- Tzaneion General Hospital (GR)
- Evangelismos Hospital (GR)
Publication Details
- Journal
- Critical Care Medicine
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1097/ccm.0000000000007026
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00