Assessing an fMRI-guided titration paradigm for microburst VNS therapy
Titration of VNS using an fMRI-guided approach is feasible and safe in PwE (when using appropriate investigational devices), but our specific biomarker, used in this specific study design, was ultimately too variable to be used for patient-specific titration. An increase in thalamic BOLD signal that occurred across multiple stimulation parameter combinations and multiple visits with microburst settings was associated with seizure response that could be visualized early in the titration process.
Authors
- Kristl E.J. Vonck (ORCID: https://orcid.org/0000-0002-2671-2650)
- Jerzy P. Szaflarski (ORCID: https://orcid.org/0000-0002-5936-6627)
- Jason Begnaud
- Ryan Verner
- Cornelia Drees
- Rebecca O’Dwyer
- Muhammad Zafar
- Roshani Patel
- Lesley Kaye
- William O Tatum
- Giovanni Ranuzzi
Institutions
- Rush University Medical Center (US)
- Ghent University Hospital (BE)
- Jacksonville College (US)
- University of Alabama at Birmingham (US)
- Ghent University (BE)
- LivaNova (United Kingdom) (GB)
- Mayo Clinic in Florida (US)
- Duke University Hospital (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Epilepsy Research
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1016/j.eplepsyres.2026.107734
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00