Grhl3 Downregulation Facilitates ECM Adaptation for Fibroblast to iCM Commitment
Our findings establish ECM adaptation as a critical determinant of cardiac reprogramming and identify Grhl3 as a promising therapeutic target to advance myocardial repair strategies.
Authors
- M. Y. Liu (ORCID: https://orcid.org/0009-0005-6574-2317)
- Zhangyi Yu (ORCID: https://orcid.org/0000-0001-8342-5044)
- Dongyu Gu
- Hong Ma (ORCID: https://orcid.org/0000-0001-7222-7376)
- X. Wu
- Zhenhua Jia
- Yanggan Wang
- Lanbing Liu
- Yi Ling
- Li Wang
- Fang Luo
Institutions
- Wuhan University (CN)
- Yangtze Optical Electronic (China) (CN)
- Hubei Provincial Center for Disease Control and Prevention (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- L-3 Communications (United States) (US)
- Zhejiang University (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1161/circresaha.125.327726
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00