Silencing myeloid cell leukemia-1 improves apoptotic and ferroptotic responses in melanoma
Overall, our findings pinpoint that Mcl-1 operates as a multifaceted survival node in melanoma, concurrently sustaining proliferation, migration, and redox homeostasis while suppressing apoptotic and ferroptotic death programs. Dual targeting of Mcl-1 and the ferroptosis pathway may offer a robust therapeutic strategy against melanoma.
Authors
- Wang Sh
- CHENGBEI BAO
- Qiuyun Xu (ORCID: https://orcid.org/0000-0002-8782-2773)
- Yang Li (ORCID: https://orcid.org/0000-0001-8186-2435)
- Shuyi Shen
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1186/s40001-026-03833-y
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00