Association of apolipoprotein B and excess apolipoprotein B with cardiovascular risk in type 2 diabetes: a prospective cohort study of the UK Biobank
In T2DM, apoB is independently associated with ASCVD but adds limited discrimination over conventional lipids. Excess apoB yielded improved discrimination and reclassification, and may serve as a complementary ASCVD risk marker, particularly in statin-treated settings. However, its clinical application requires external validation and standardization.
Authors
- Xuehai Zhang (ORCID: https://orcid.org/0000-0001-7734-706X)
- Junchao Che
- Jiayan Lyu
- Yang Yu (ORCID: https://orcid.org/0000-0002-1743-7458)
- Lijuan Lyu
- Jin Su
- Jie Zhang
- Chunyu Kao
Institutions
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1186/s12944-025-02852-8
- Citations
- 1
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 39.15