ACTIVE COURSE OF HERPES VIRUS INFECTION IN EARLY CHILDREN

ACTIVE COURSE OF HERPES VIRUS INFECTION IN EARLY CHILDREN Yusupova Nargiza Abdikodirovna, Manonova Nigina Oktamovna, Mirzayeva Bibiniso Ismatulla qizi, Amirova Durdona Olim qizi [email protected] Department of Clinic laboratory diagnostic of Samarkand State Medical University. Uzbekistan, Samarkand city, Amir Temur street 18, Tel: +998 66 2330841 E-mail: [email protected]. https://doi.org/10.5281/zenodo.18261340 ABSTRACT: Herpesvirus infections are common among young children and represent a significant medical and social problem due to the variety of clinical manifestations and the risk of protracted or recurrent disease. Active forms of herpesvirus infection, characterized by severe clinical symptoms and involvement of various organs and systems, attract particular attention. The aim of the study was to investigate the clinical and laboratory characteristics of active herpesvirus infection in young children. Materials and Methods: A total of 122 young children (up to 3 years of age) with markers of active herpesvirus infections (HVI) were observed. The markers were studied by PCR in blood, tonsil swab, saliva, cerebrospinal fluid, urine with the determination of HSV type 1-2, EBV, CMV, HHV-6 DNA; antigens of the specified herpes viruses in blood lymphocytes were determined by the indirect immunofluorescence reaction (IRIF) and rapid culture method (RCM); IgM and IgG antibodies were determined in blood serum by the ELISA method. Results. It was established that herpesvirus infection occurs at an early age and contributes to the development of various infectious and somatic pathologies. In children from birth to 1 year of age, CMV infection is most often detected (in 79% of cases) as a monoinfection with symptoms of CNS damage, generalized forms, neutropenia. In children aged 1 to 2 years, HHV-6 infection is detected in 76% of cases, most often in mixed variants. Patients in this group present with prolonged subfebrile fever, neutropenia, and infectious mononucleosis. In the third year of life, an increase in EBV infection in children is observed, with approximately equal frequencies of EBV and HHV-6, most often in mixed forms, the clinical manifestation of which is a typical symptom complex of infectious mononucleosis. At this age, active persistence of herpesviruses contributes to the formation of a group of frequently ill children. Conclusion. Thus, when examining young children with various pathologies, it is necessary to diagnose herpesvirus infection using modern methods for detecting its active forms for the timely administration of etiotropic therapy. Key words: herpesvirus infections, EBV, CMV, HHV-6, active forms, diagnostics, young children Keywords: herpesvirus infections, EBV, CMV, HHV-6, active forms, diagnosis, young children.