Molecular characterization of clear cell adenocarcinoma of the urinary bladder
In summary, we identified a distinct oncogenic pathway in CCA of the urinary bladder, most commonly involving activation of the PI3K/AKT/mTOR pathway through gain-of-function mutations in PIK3CA (74%) and/or KRAS (26%). These tumours frequently harbour loss-of-function mutations in tumour suppressor genes (TP53, SMAD4, RB1 and APC) and point/missense mutations of proto-oncogenes (ERBB2 and MET). Our study also highlights potential therapeutic targets for this aggressive malignancy.
Authors
- Sean R. Williamson (ORCID: https://orcid.org/0000-0002-3898-1460)
- Mahmut Akgül (ORCID: https://orcid.org/0000-0003-0929-0940)
- Anandi Lobo (ORCID: https://orcid.org/0000-0002-3051-8009)
- Nada Shaker
- Shilpy Jha
- Shivani Kandukuri
- Sudhasmita Routa
- Ekta Jain (ORCID: https://orcid.org/0009-0009-8176-059X)
- Manas Baisakh
- Anil Parwani
- Jasreman Dhillon
- Sambit K Mohanty
- Sourav K Mishra
- Andres M Acosta
- Liang Cheng
- Niharika Pattnaik
- Ankur R Sangoi
- Shivani Sharma
- Aditi Aggarwal
- Samriti Arora
Institutions
- Brigham and Women's Hospital (US)
- Cleveland Clinic (US)
- University of California, Irvine (US)
- Brown University (US)
- The Ohio State University Wexner Medical Center (US)
- Moffitt Cancer Center (US)
- University of Alabama at Birmingham (US)
- All India Institute of Medical Sciences Bhubaneswar (IN)
- Stanford Medicine (US)
- D.A.V Centenary Dental College (IN)
- Manipal Hospital (IN)
- Indiana University – Purdue University Indianapolis (US)
- All India Institute of Medical Sciences (IN)
- Icahn School of Medicine at Mount Sinai (US)
- Core Laboratories (United States) (US)
Publication Details
- Journal
- Histopathology
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1111/his.70096
- Citations
- 1
- Primary Topic
- Urinary and Genital Oncology Studies
- Type
- article
- Field-Weighted Citation Impact
- 39.15