Wilson’s disease-associated gut dysbiosis: novel insights into microbial functional alterations, virulence changes, and resistance markers
Wilson's disease (WD) patients exhibit significant alterations in gut microbial community structure and functional dysbiosis, wherein the enrichment of virulence genes (such as colibactin genes <i>clbB</i>/<i>clbH</i>) and the specific antibiotic resistance genes (such as <i>tetQ</i> and <i>ErmB</i>), and the activation of mobile genetic elements are closely associated with clinical indicators including liver function impairment, coagulation abnormalities, and lipid metabolism disorders.
Authors
- Fei Xu (ORCID: https://orcid.org/0000-0003-1077-0431)
- Yangyang Li
- Yuqi Song (ORCID: https://orcid.org/0009-0000-8148-9212)
- Weiqi Wang (ORCID: https://orcid.org/0009-0008-1561-7472)
- Nannan Qian
- Zihao Zhao
- Han Wang
- Taohua Wei
- Wenming Yang
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Anhui University of Traditional Chinese Medicine (CN)
- National Science Centre (PL)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-01-15
- DOI
- https://doi.org/10.3389/fmicb.2025.1714276
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Anhui University
- Anhui University of Chinese Medicine