Case Report: Triple autoimmune overlap: rheumatoid arthritis, systemic lupus erythematosus, and hypereosinophilic asthma with systemic manifestations

New-onset eosinophilic asthma in patients with established rheumatic disease should prompt evaluation for EGPA-spectrum or hypereosinophilic disorders. Even when the final label is HASM rather than definite EGPA, timely institution of EGPA-type immunosuppression may avert organ damage.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-01-15
DOI
https://doi.org/10.3389/fimmu.2025.1659370
Primary Topic
Vasculitis and related conditions
Type
article
Field-Weighted Citation Impact
0.00
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article

Case Report: Triple autoimmune overlap: rheumatoid arthritis, systemic lupus erythematosus, and hypereosinophilic asthma with systemic manifestations

R. Yu, Yanfeng Zhang, Jinbo Li, Shengguang Li et al.
Frontiers in Immunology
Vasculitis and related conditions
article

Case Report: Triple autoimmune overlap: rheumatoid arthritis, systemic lupus erythematosus, and hypereosinophilic asthma with systemic manifestations

R. Yu, Yanfeng Zhang, Jinbo Li, Shengguang Li, Ting Long, Yadan Zou, Jing Zhang, Lina Zhang
article en

Abstract

New-onset eosinophilic asthma in patients with established rheumatic disease should prompt evaluation for EGPA-spectrum or hypereosinophilic disorders. Even when the final label is HASM rather than definite EGPA, timely institution of EGPA-type immunosuppression may avert organ damage.

Frontiers in ImmunologyVol. 16
Peking University (CN), Peking University International Hospital (CN)
Openalex Percentile: Top 88%
Vasculitis and related conditions
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Case Report: Triple autoimmune overlap: rheumatoid arthritis, systemic lupus erythematosus, and hypereosinophilic asthma with systemic manifestations — R. Yu, Yanfeng Zhang, et al. · Frontiers in Immunology (2026) | TGRS Research Map | TGRS