Incidentally Detected Splenomegaly and Risk of Hematologic Cancer and Liver Disease
In this cohort study, absolute 5-year risks of hematologic cancers, cirrhosis, and liver cancer were calculated according to spleen size, age, and sex. Absolute 5-year risks of any hematologic cancer were moderately increased for spleen length of 130 to 139 mm or spleen volume of 400 to 499 mL and markedly increased in individuals with spleen length of 140 mm or greater or spleen volume of 500 mL or greater, indicating that clinical workup may likely be relevant.
Authors
- Anne Rudbeck Juhl (ORCID: https://orcid.org/0000-0003-2457-0182)
- S. Bojesen
- B G. Nordestgaard
- Per Ejlstrup Sigvardsen (ORCID: https://orcid.org/0000-0003-1922-0479)
- Jørgen Tobias Kühl (ORCID: https://orcid.org/0000-0002-7726-689X)
- Andreas Fuchs (ORCID: https://orcid.org/0000-0003-0236-0811)
- Jens Helby (ORCID: https://orcid.org/0000-0002-1876-8187)
- Andreas Glenthøj (ORCID: https://orcid.org/0000-0003-2082-0738)
- Thomas Skårup Kristensen (ORCID: https://orcid.org/0000-0002-7305-0880)
- J. Petersen (ORCID: https://orcid.org/0000-0003-4175-9649)
- Rasmus Rønnemoes (ORCID: https://orcid.org/0009-0003-0254-6808)
- Michael Huy Cuong Pham
Institutions
- University of Copenhagen (DK)
- Hvidovre Hospital (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
Publication Details
- Journal
- JAMA Oncology
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1001/jamaoncol.2025.5934
- Primary Topic
- Abdominal Trauma and Injuries
- Type
- article
- Field-Weighted Citation Impact
- 0.00