Unveiling the IL-1β/CXCL2 axis: a shared therapeutic target in periodontitis and inflammatory bowel disease
Our integrative analyses identify a shared, myeloid-centered IL-1β/chemokine inflammatory program across periodontitis and IBD, which may contribute to the oral-gut inflammatory axis. The IL1β-CXCL2 pathway represents a potentially targetable signaling module, although functional blockade studies are required to establish therapeutic causality.
Authors
- Aichao Gao
- Caiqing Qiu
- Y. Zhang
- Xiang Ma (ORCID: https://orcid.org/0000-0003-2285-9206)
- Xiaotong Wang
- Zhongyi Gu
- Yucun Wang
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1728773
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00