Comprehensive Transcriptome Profiling of Sporadic Medullary Thyroid Carcinomas

Medullary thyroid carcinoma (MTC) is a rare thyroid cancer arising from parafollicular C cells belonging to the heterogeneous class of neuroendocrine neoplasms. Mutations in the RET and RAS genes are detected in approximately 50% to 80% of sporadic MTCs, while other genetic alterations are relatively uncommon. Only a few transcriptomic studies of this neoplasia have been performed, and the biology and the molecular mechanisms underlying its progression remain largely unknown. In this study, we performed transcriptome profiling of a cohort comprising 72 MTC specimens from patients with different genetic backgrounds. The presented data highlighted the molecular heterogeneity of MTCs and the need for personalized treatment strategies. For this reason, the obtained profiles could offer novel perspectives into the molecular landscape of this neoplasm within the scientific community.

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Publication Details

Journal
Scientific Data
Published
2026-01-15
DOI
https://doi.org/10.1038/s41597-026-06550-7
Primary Topic
Thyroid Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Comprehensive Transcriptome Profiling of Sporadic Medullary Thyroid Carcinomas

Roberta Tarallo, Domenico Rocco, Viola Melone, Caterina Mian et al.
Scientific Data
Thyroid Cancer Diagnosis and Treatment
article

Comprehensive Transcriptome Profiling of Sporadic Medullary Thyroid Carcinomas

Roberta Tarallo, Domenico Rocco, Viola Melone, Caterina Mian, Simona Censi, Maria Chiara Zatelli, Susi Barollo, Loris Bertazza, Alessandro Weisz, Luigi Palo, Mario Vitale, Fabio Russo, Domenico Palumbo
article en

Abstract

Medullary thyroid carcinoma (MTC) is a rare thyroid cancer arising from parafollicular C cells belonging to the heterogeneous class of neuroendocrine neoplasms. Mutations in the RET and RAS genes are detected in approximately 50% to 80% of sporadic MTCs, while other genetic alterations are relatively uncommon. Only a few transcriptomic studies of this neoplasia have been performed, and the biology and the molecular mechanisms underlying its progression remain largely unknown. In this study, we performed transcriptome profiling of a cohort comprising 72 MTC specimens from patients with different genetic backgrounds. The presented data highlighted the molecular heterogeneity of MTCs and the need for personalized treatment strategies. For this reason, the obtained profiles could offer novel perspectives into the molecular landscape of this neoplasm within the scientific community.

Scientific DataVol. 13(1)
University of Salerno (IT), University of Padua (IT), University of Ferrara (IT), Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona (IT), Center for Genomic Science (IT)
Università degli Studi di Salerno
Good health and well-being
Openalex Percentile: Top 87%
Thyroid Cancer Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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Comprehensive Transcriptome Profiling of Sporadic Medullary Thyroid Carcinomas — Roberta Tarallo, Domenico Rocco, et al. · Scientific Data (2026) | TGRS Research Map | TGRS