Elevated methylmalonic acid, but not vitamin B12, predicts all-cause mortality in hyperlipidemic adults: a prospective cohort study
Elevated serum MMA and functional vitamin B12 deficiency are significantly associated with increased all-cause mortality in hyperlipidemia, whereas serum vitamin B12 level alone lacks independent prognostic value. MMA may serve as a novel biomarker for mortality risk in hyperlipidemia population, highlighting the clinical importance of assessing functional vitamin B12 status.
Authors
- Hong Yang (ORCID: https://orcid.org/0000-0002-2232-1847)
- Gongshuang Zhao
- Baiqiang Wang
- Chenghu Guo (ORCID: https://orcid.org/0000-0002-1910-6599)
- Xiao Zhang (ORCID: https://orcid.org/0000-0001-5050-2621)
- Lianyue Ma
- Leiyang Li
- Chengzhi Li
- Qingtao Gong
- Guipeng An
Institutions
- Shandong University (CN)
- Jinan Maternity And Care Hospital (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2026-01-15
- DOI
- https://doi.org/10.3389/fnut.2026.1742540
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Shandong Province
- China International Medical Foundation