Frontal skin metastasis from undifferenciated carcinoma of nasopharynx: a case report

Cutaneous metastasis in nasopharyngeal carcinoma is a rare entity but carries a poor prognosis, reflecting an advanced phase of the disease. The most frequent metastatic sites are located in the head and neck region, while frontal involvement is exceedingly uncommon. We report the case of a 56-year-old woman with no significant medical history who was diagnosed four years earlier with undifferentiated carcinoma of the nasopharyngeal type (UCNT). The patient underwent concomitant radiochemotherapy, achieving complete remission for three years, then the patient was lost to follow-up for two years and later presented with recurrent nasal obstruction and a frontal cutaneous lesion, initially nodular and subsequently ulcerated. Endoscopic and radiological evaluation, along with biopsy, confirmed recurrence of nasopharyngeal carcinoma with nodal metastasis and frontal cutaneous metastasis. The patient was referred to oncology for second-line treatment.