Comparison of “Continuous” and “End-ischemic” Approaches of Oxygenated Hypothermic Machine Perfusion for Pancreas Preservation
Continuous HMPO<sub>2</sub> is a superior method for preserving beta-cell function compared with SCS and end-ischemic HMPO<sub>2</sub> in a porcine model of circulatory death when assessed by NR with whole blood as a surrogate for transplantation. As end-ischemic HMPO<sub>2</sub> is also feasible and potentially superior to SCS, testing its safety would be an excellent first step in translating this technology into clinical practice.
Authors
- Benoît Hastoy (ORCID: https://orcid.org/0000-0003-1244-7857)
- James Hunter (ORCID: https://orcid.org/0000-0002-4972-6879)
- Sameena Nawaz (ORCID: https://orcid.org/0000-0002-3894-4600)
- A. Clark
- Maria Letizia Lo Faro
- John Fallon
- Peter Friend
- Julien Branchereau
- Mohamed Aly Mohamed Elshafei Elzawahry
- Rutger Ploeg
Institutions
- Inserm (FR)
- University of Oxford (GB)
- Institut de Transplantation Urologie en Nephrologie (FR)
- Oxford Centre for Diabetes, Endocrinology and Metabolism (GB)
- Oxford BioMedica (United Kingdom) (GB)
- Nantes Université (FR)
Publication Details
- Journal
- Transplantation Direct
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1097/txd.0000000000001888
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Diabetes UK
- University of Oxford