Multi-omics elucidation of Lactiplantibacillus plantarum NKK20 in preventing PCOS via the gut-ovary axis: SCFAs-mediated microbiota-metabolite-immune crosstalk
Collectively, these findings delineate a novel preventive axis through which LP inhibits PCOS progression - namely, via coordinated "gut microbiota-metabolite-ovarian" crosstalk involving SCFA-mediated barrier restoration, microbial ecology stabilization, and suppression of ovarian inflammatory onset. This work advances the translational rationale for probiotic-based strategies in PCOS prevention.
Authors
- Asmaa Ali (ORCID: https://orcid.org/0000-0002-7421-5085)
- Jiayuan He
- Xinyu Liu (ORCID: https://orcid.org/0000-0002-2793-0190)
- Yuchen Xie (ORCID: https://orcid.org/0000-0003-4838-7681)
- Jie Ma (ORCID: https://orcid.org/0000-0002-7344-5145)
- Wen Sun (ORCID: https://orcid.org/0009-0006-7749-9649)
- Hao Xu (ORCID: https://orcid.org/0000-0002-9036-8786)
- Xueyun Dong
- Keke Shao
- Xuehui Liu
- Min Chen
- Liang Wu
Institutions
- Jiangsu University (CN)
- Ludovika University of Public Service (HU)
- Xuzhou Medical College (CN)
- Nantong University (CN)
- Xinjiang Uygur Autonomous Region Disease Prevention and Control Center (CN)
- Jiangsu Vocational College of Medicine (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Yancheng First People's Hospital (CN)
- Taiwan Centers for Disease Control (TW)
- ABB (Switzerland) (CH)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2026-01-15
- DOI
- https://doi.org/10.3389/fnut.2025.1709581
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China