Antifouling compounds from marine fungus <i>Aspergillus iizukae</i> GXIMD 00548
Twenty-three phenolic acids (<b>1</b>-<b>23</b>), including three novel sulfur-containing derivatives, along with five alkaloids (<b>24</b>-<b>28</b>) were isolated from the marine-derived fungus <i>Aspergillus iizukae</i> GXIMD 00548. Their structures were elucidated through comprehensive spectroscopic analysis and comparison with literature. All isolated compounds were evaluated for antifouling activities against barnacle larval settlement. Compounds <b>1</b>-<b>6</b>, <b>8</b>-<b>11</b>, <b>13</b>, <b>20</b>, <b>22</b> and <b>24</b>-<b>26</b> exhibited potent antifouling effects with median effect concentration (EC<sub>50</sub>) values ranging from 0.03 to 11.03 μg/mL. Additionally, compounds <b>9</b>, <b>10</b> and <b>13</b> showed acetylcholinesterase (AChE) inhibitory effects with half maximal inhibitory concentration (IC<sub>50</sub>) values of 49.67 ± 0.08, 77.69 ± 0.09, and 127.5 ± 0.09 μM, respectively.
Authors
- Xinya Xu
- Hui Huang (ORCID: https://orcid.org/0000-0003-1212-496X)
- Xiao-wei Luo
- Chaoqi Chen (ORCID: https://orcid.org/0000-0002-5645-7718)
- Chun-Qing Fu
- C. H. Gao
- Meng-Fan Qi
- Yong-Hong Liu (ORCID: https://orcid.org/0000-0001-8327-3108)
Institutions
- Guangxi University (CN)
- Guangxi University of Chinese Medicine (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Biofouling
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1080/08927014.2025.2610823
- Primary Topic
- Marine Biology and Environmental Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00