Persistent Immunity From Historic Smallpox Vaccination and Its Limited Cross-Neutralization of Monkeypox Virus: A Population-based Serological Study in Taiwan
Historical smallpox vaccination induces long-lasting humoral immunity, and a correlation between VACV and MPXV antibody levels further suggests that it provides some degree of cross-protection against MPXV infection. MVA-BN boosted orthopoxvirus immunity; however, it may be limited in MPXV neutralization in vaccine-naïve populations. These findings offer useful insights for future mpox vaccination strategies and public health planning in regions with varying smallpox vaccination histories.
Authors
- Le-Tien Lin (ORCID: https://orcid.org/0000-0003-0105-4206)
- A. Chen
- Y. U.Chen Hung
- C. F. Huang
- Wen-Hui Fang
- Yen-Chen Chen
Institutions
- National Defense Medical Center (TW)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2026-01-12
- DOI
- https://doi.org/10.1093/ofid/ofag018
- Primary Topic
- Poxvirus research and outbreaks
- Type
- article
- Field-Weighted Citation Impact
- 0.00