Accelerated brain aging in amyotrophic lateral sclerosis and its prognostic associations: a cohort study
Accelerated brain aging is common in ALS; this could be hypothesized to be associated with the interplay between BBB breakdown and neuroinflammation, leading to gray matter degeneration. Furthermore, older brain age at initial diagnosis is associated with worse clinical outcomes. These findings suggest that therapeutic strategies targeting neuroinflammation and BBB integrity may help attenuate accelerated brain aging and improve prognosis.
Authors
- Fangfang Hu (ORCID: https://orcid.org/0000-0002-8959-7581)
- Sheng He (ORCID: https://orcid.org/0000-0001-5547-923X)
- Shan Wu (ORCID: https://orcid.org/0009-0008-5161-2003)
- Wen Shi (ORCID: https://orcid.org/0000-0003-4957-7786)
- dengdi sun
- Qianqian Duan
- Haining Li
- Xinyi Yu
- Xin Qin
- Shuoqiu Gan
- Chenhao Fang
- Ming Zhang
- Jingxia Dang
- Qiuli Zhang
- Xiaoyu Xu
- Tao Lu
- Jun Huang
- Jiaoting Jin
- Qing He
Institutions
- Anhui University (CN)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Institute of Biophysics (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- National Science Centre (PL)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1186/s12916-026-04631-3
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00