Helminth Antigens Modulate Virus-Induced Activation of CD154 (CD40L) Expression on T Cells in Onchocerca volvulus-Infected Individuals
These findings demonstrate that helminth antigens modulate functional SARS-CoV-2-induced T-cell responses, offering a potential mechanism through which helminth co-infections shape antiviral immunity, vaccine efficacy, and clinical disease outcomes.
Authors
- Tomabu Adjobimey (ORCID: https://orcid.org/0000-0002-4353-2897)
- John Boateng (ORCID: https://orcid.org/0000-0003-1309-2840)
- Ute Klarmann‐Schulz (ORCID: https://orcid.org/0000-0001-5826-0196)
- Alexander Yaw Debrah (ORCID: https://orcid.org/0000-0001-5721-0891)
- Manuel Ritter (ORCID: https://orcid.org/0000-0001-8667-2067)
- Kathrin Arndts (ORCID: https://orcid.org/0000-0003-1091-4861)
- Derrick Adu Mensah
- Vera Serwaa Opoku (ORCID: https://orcid.org/0000-0001-7950-6650)
- Jubin Osei-Mensah (ORCID: https://orcid.org/0000-0003-3470-2994)
- M. D. Owusu Owusu
- Brice Armel Nembot Fogang
- Inge Kroidl
- Achim Hoerauf
- Linda B. Debrah
- Sacha Horn
- Julia Meyer
Institutions
- University of Bonn (DE)
- Kwame Nkrumah University of Science and Technology (GH)
- German Center for Infection Research (DE)
- Université d'Abomey-Calavi (BJ)
- Kumasi Centre for Collaborative Research in Tropical Medicine (GH)
- Institute of Medical Microbiology and Hygiene (DE)
- Ludwig-Maximilians-Universität München (DE)
- University for Development Studies (GH)
Publication Details
- Journal
- Pathogens
- Published
- 2026-01-15
- DOI
- https://doi.org/10.3390/pathogens15010093
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kwame Nkrumah University of Science and Technology