Specific associations of serum FGF23 and soluble Klotho with different types of left ventricular hypertrophy in hypertensive peritoneal dialysis patients: a cross-sectional study

Among hypertensive PD patients, serum soluble α-Klotho is an independent protective biomarker for LVH, while elevated FGF23 levels are associated with an increased risk of LVH, suggesting an interaction between the two. FGF23 demonstrates a non-linear association with LVMI, which is modified by age and gender. Concurrent measurement of FGF23 and soluble α-Klotho may help identify patients at high risk for cardiovascular remodelling, thereby informing risk stratification and personalized management strategies.