CXCL12 promotes EMT-mediated malignant transformation of endometriosis-associated ovarian cancer via PI3K/Akt signaling: An integrated transcriptomic and clinical study

This study is the first to systematically define the critical role of CXCL12 in the malignant transformation of endometriosis to EAOC.Our findings demonstrate that CXCL12 promotes tumor cell invasion and metastasis through PI3K/Akt-mediated induction of EMT. These results provide novel insights into the pathogenesis of EAOC and highlight CXCL12 as a promising biomarker for early diagnosis and a potential therapeutic target, offering new avenues for precision management of EAOC.