Cryoablation: A Minimally Invasive Alternative for Early-Stage Breast Cancer: 6-Year Outcomes of the FROST Clinical Trial

The FROST trial adds to the growing body of literature supporting the efficacy and safety of cryoablation and supports ongoing research on cryoablation as a strategy for de-escalating breast cancer therapy.

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Publication Details

Journal
Annals of Surgical Oncology
Published
2026-01-15
DOI
https://doi.org/10.1245/s10434-025-18991-2
Primary Topic
Ultrasound and Hyperthermia Applications
Type
article
Field-Weighted Citation Impact
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article

Cryoablation: A Minimally Invasive Alternative for Early-Stage Breast Cancer: 6-Year Outcomes of the FROST Clinical Trial

K. Kozlowski, L. Kruper, M. Plaza, S. Manoian et al.
Annals of Surgical Oncology
Ultrasound and Hyperthermia Applications
article

Cryoablation: A Minimally Invasive Alternative for Early-Stage Breast Cancer: 6-Year Outcomes of the FROST Clinical Trial

K. Kozlowski, L. Kruper, M. Plaza, S. Manoian, S. Patterson, D. R. Holmes, P. Littrup, L. Bailey, J. Tamayo, S. Abe, V. Jones, R. C. Ward, N. Z. Carp, R. Layeequr Rahman
article en

Abstract

The FROST trial adds to the growing body of literature supporting the efficacy and safety of cryoablation and supports ongoing research on cryoablation as a strategy for de-escalating breast cancer therapy.

Annals of Surgical OncologyVol. 33(4)
Texas Tech University (US), University of California, San Francisco (US), Brown University (US), Naples Community Hospital Healthcare System (US), Lankenau Medical Center (US), University of Rochester Medical Center (US), Moffitt Cancer Center (US), Virginia Oncology Associates (US), Analytical Mechanics Associates (United States) (US), Beverly Hills Cancer Center (US), Southwest Regional Wound Care Center (US), Arnot Ogden Medical Center (US), City of Hope (US), Naples Anesthesia & Physician Associates (US), Adventist Health Glendale (US), Epic Care (US), Crittenton Hospital Medical Center (US), Hampton Roads Sanitation District (US), Alta Bates Summit Medical Center (US), Texas Tech University Health Sciences Center (US)
Good health and well-being
Openalex Percentile: Top 87%
Ultrasound and Hyperthermia Applications
DOIOpen Access PDFOpenAlex
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Cryoablation: A Minimally Invasive Alternative for Early-Stage Breast Cancer: 6-Year Outcomes of the FROST Clinical Trial — K. Kozlowski, L. Kruper, et al. · Annals of Surgical Oncology (2026) | TGRS Research Map | TGRS