Sex‐related susceptibility to pulmonary fibrosis development in mice
Our data suggest that while inflammation occurs in both males and females during the early stages of PF induction, exacerbated fibrosis is observed only in males. Additionally, pirfenidone demonstrated greater activity in male mice, highlighting the need to consider potential sex-specific pharmacotherapy.
Authors
- Cristina Quintavalle (ORCID: https://orcid.org/0000-0002-7432-9170)
- Martina Simonelli (ORCID: https://orcid.org/0000-0002-0185-4281)
- Danilo D’Avino (ORCID: https://orcid.org/0000-0002-6350-5191)
- Antonietta Rossi (ORCID: https://orcid.org/0000-0002-3237-2584)
- Armando Ialenti (ORCID: https://orcid.org/0000-0002-8046-0116)
- Ida Cerqua (ORCID: https://orcid.org/0000-0002-4363-7728)
- Elisabetta Granato (ORCID: https://orcid.org/0000-0002-7207-5832)
- Sara Perna
- Fabio Cattaneo (ORCID: https://orcid.org/0000-0002-5833-8333)
- Simona Pace (ORCID: https://orcid.org/0000-0001-5110-481X)
- Fiorentina Roviezzo (ORCID: https://orcid.org/0000-0003-1582-7396)
- D Galati
- Patrick Schädel (ORCID: https://orcid.org/0000-0002-9586-6653)
- Myrhiam Cassese
- Oliver Werz
- Katharina P. L. Meyer
- Lucianna Maruccio
Institutions
- University of Salerno (IT)
- The University of Texas MD Anderson Cancer Center (US)
- San Raffaele University of Rome (IT)
- Institute for Experimental Endocrinology and Oncology (IT)
- Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
- University of Naples Federico II (IT)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1111/bph.70304
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00