FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway
FOXO4-DRI promotes the nuclear export of phosphorylated P53 by inhibiting the binding of FOXO4 to P53 in endothelial cells, thereby facilitating the apoptosis of senescent endothelial cells and alleviating aging.
Authors
- Chunyi Hu (ORCID: https://orcid.org/0000-0003-4509-4840)
- Xixi Chen (ORCID: https://orcid.org/0000-0002-9898-6255)
- Litai Jin (ORCID: https://orcid.org/0000-0002-7598-5938)
- F. Li
- Xu Wang (ORCID: https://orcid.org/0000-0001-9064-2434)
- Xiaojing Yi
- Zhouhao Tang
- Meifan Jiang
- Qiongdan Shan
- Yang Wang
- Zhicheng Hu
Institutions
- Wenzhou Medical University (CN)
- Zhejiang Lab (CN)
- Taizhou Central Hospital (CN)
- Ningbo College of Health Sciences (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2026-01-15
- DOI
- https://doi.org/10.3389/fbioe.2025.1729166
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China