Adenovector 26 Encoded RSV Prefusion F Protein (Ad26.RSV.preF) Does Not Predispose to Enhanced Respiratory Disease in Preclinical Rodent Models
Based on these extensive analyses, we conclude that there are no indications of ERD predisposition after Ad26.RSV.preF vaccination in rodent models, irrespective of the vaccine dose, challenge virus strain, or presence of viral replication in the lung. These results are crucial for the pediatric development of this vaccine.
Authors
- Renske Bolder (ORCID: https://orcid.org/0000-0001-7539-4524)
- Leslie van der Fits
- Zahn Roland
- Susan B. S. King
Institutions
- Johnson & Johnson (Netherlands) (NL)
Publication Details
- Journal
- Vaccines
- Published
- 2026-01-15
- DOI
- https://doi.org/10.3390/vaccines14010087
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00