NRF2–COX2–PGE2 axis drives immune cold tumors and predicts resistance to combination immunotherapy in hepatocellular carcinoma

Tumor-intrinsic activation of the NRF2-COX2-PGE 2 axis drives immune cold TMEs and mediates Atez/Bev resistance in HCC. Targeting this pathway may enhance efficacy, and plasma PGE 2 represents a non-invasive biomarker for stratification.

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Publication Details

Journal
Hepatology
Published
2026-01-15
DOI
https://doi.org/10.1097/hep.0000000000001677
Citations
1
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
36.44
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NRF2–COX2–PGE2 axis drives immune cold tumors and predicts resistance to combination immunotherapy in hepatocellular carcinoma

Haruhiko Takeda, Kazuki Maesaka, Kenta Motomura, Takahiro Kodama et al.
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Hepatology
Ferroptosis and cancer prognosis
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article

NRF2–COX2–PGE2 axis drives immune cold tumors and predicts resistance to combination immunotherapy in hepatocellular carcinoma

Haruhiko Takeda, Kazuki Maesaka, Kenta Motomura, Takahiro Kodama, Shunsuke Yamamoto, Yuta Myojin, Hideo Shindou, Kazuhiro Murai, Yuki Tahata, Akifumi Kuwano, Amaia Lujambio, Akinobu Taketomi, Hayato Hikita, Tasuku Nakabori, Masanori Miyazaki, Tomomi Yoshida-Hashidate, Yasutoshi Nozaki, Kumiko Shirai, Kazuyoshi Ohkawa, Yuki Makino, Atsushi Hosui, Akira Nishio, Satoshi Tanaka, Tetsuo Takehara
article en
1 citations

Abstract

Tumor-intrinsic activation of the NRF2-COX2-PGE 2 axis drives immune cold TMEs and mediates Atez/Bev resistance in HCC. Targeting this pathway may enhance efficacy, and plasma PGE 2 represents a non-invasive biomarker for stratification.

Hepatology
Osaka Gakuin University (JP), Hokkaido University (JP), Kyoto University (JP), Osaka National Hospital (JP), National Center for Global Health and Medicine (JP), Osaka Rosai Hospital (JP), Kansai Rosai Hospital (JP), Osaka Hospital (JP), Japan Community Healthcare Organization (JP), Aso Iizuka Hospital (JP), Osaka International Cancer Institute (JP), The University of Tokyo (JP), The University of Osaka (JP), Icahn School of Medicine at Mount Sinai (US)
No poverty
Openalex Percentile: Top 2%
Ferroptosis and cancer prognosis
36.44
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