Physical Exercise for Managing Fatigue in Parkinson’s Disease: Clinical and Research Recommendations From a Systematic Review and Meta-Analysis

Moderate-certainty evidence supports that physical exercise, particularly active, continuous modalities such as walking, aerobic, resistance, and multimodal training at moderate intensity (at least twice weekly for 20-60 minutes), can reduce PD-related fatigue. Future research should distinguish between central and peripheral fatigue, compare high-intensity exercise interventions, and explore combinations of exercise with other promising interventions.