Predictors of lymph node metastasis in resectable pancreatic neuroendocrine neoplasms: a single-center retrospective study

The preoperative MLR, vascular invasion, peripheral nerve invasion, bilirubin level, tumor grade and tumor size are potential predictors of LNM, especially during the initial diagnosis of resectable pNENs. Multivariate ROC analysis demonstrated superior performance by incorporating variables significant in univariate analysis. These factors combined can assist in clinical decision-making, such as more aggressive early intervention or intensive follow-up.