FSCN1 induces subchondral bone sclerosis in osteoarthritis via modulating actin cytoskeleton dynamics and YAP signaling
This study suggests that FSCN1 is a key factor in the relationship between mechanical stress, actin cytoskeleton dynamic, subchondral bone sclerosis and OA pathology. Targeting FSCN1 represents a promising pharmacological approach for OA therapy.
Authors
- D. Chen
- Chao Yang (ORCID: https://orcid.org/0000-0001-7724-0385)
- Jinyan Li (ORCID: https://orcid.org/0009-0008-5129-3460)
- Panpan Yang (ORCID: https://orcid.org/0000-0002-8979-4681)
- Yun Xiao
- Qinwei Cheng
- Zilin Zou
- Liangyu Chen
- Junfeng Wu
- Hong Wang
- Kai Li
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1186/s13075-026-03731-y
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00