White matter microstructure mediates the link between rest-activity rhythm instability and mania symptoms in individuals at risk for bipolar disorder
Rest-activity instability may disrupt fronto-limbic white matter, increasing risk to mania in those at elevated vulnerability for BD. Stabilizing rest-activity rhythms in at-risk individuals may help preserve white matter integrity and mitigate BD risk.
Authors
- Adriane M. Soehner (ORCID: https://orcid.org/0000-0003-3172-1815)
- Brant P. Hasler (ORCID: https://orcid.org/0000-0002-3123-1106)
- Simey Chan
- Lauren Keller
- Joao Paulo Lima Santos
- Danella Hafeman
- Meredith Wallace
- Lara Labardini
Institutions
- University of Pittsburgh (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-01-15
- DOI
- https://doi.org/10.64898/2026.01.13.26343956
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Mental Health