Remote digital cognitive assessment for aging and dementia using the Oxford Cognitive Testing Portal OCTAL

The global rise in dementia necessitates scalable cognitive assessments that can evolve to serve both clinical and research applications. We present the Oxford Cognitive Testing Portal (OCTAL), a remote, browser-based platform providing performance metrics for memory, attention, visuospatial and executive function domains. Four validation studies (N = 1664) confirmed cross-cultural applicability, lifespan sensitivity and clinical utility. Task performance was equivalent in English- and Chinese-speaking younger adults and mapped domain-specific ageing trajectories in mid- to late-adulthood. In a memory-clinic cohort (N = 194), 5-minute OCTAL screen distinguished patients with Alzheimer's disease dementia from subjective cognitive decline (AUC = 0.92), matching a standard paper-based test, while a 20-minute subset surpassed this (AUC = 0.97; p = 0.04). Test-retest reliability was very good (ICC ≥ 0.79; N = 118). OCTAL enables remote assessment for large-scale research and screening, with an open, modular architecture that makes it a uniquely sustainable and evolvable tool for the research community.

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Publication Details

Journal
npj Digital Medicine
Published
2026-01-15
DOI
https://doi.org/10.1038/s41746-026-02346-6
Citations
1
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
33.12

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article

Remote digital cognitive assessment for aging and dementia using the Oxford Cognitive Testing Portal OCTAL

Qian-Yuan Tang, Sijia Zhao, Sanjay Manohar, Sian Thompson et al.
1 citations
npj Digital Medicine
Dementia and Cognitive Impairment Research
33.12
article

Remote digital cognitive assessment for aging and dementia using the Oxford Cognitive Testing Portal OCTAL

Qian-Yuan Tang, Sijia Zhao, Sanjay Manohar, Sian Thompson, M. Husain, Claudia Gendarini, Anna Scholcz, Sofia Toniolo, M. John Broulidakis, Akke Ganse-Dumrath
article en
1 citations

Abstract

The global rise in dementia necessitates scalable cognitive assessments that can evolve to serve both clinical and research applications. We present the Oxford Cognitive Testing Portal (OCTAL), a remote, browser-based platform providing performance metrics for memory, attention, visuospatial and executive function domains. Four validation studies (N = 1664) confirmed cross-cultural applicability, lifespan sensitivity and clinical utility. Task performance was equivalent in English- and Chinese-speaking younger adults and mapped domain-specific ageing trajectories in mid- to late-adulthood. In a memory-clinic cohort (N = 194), 5-minute OCTAL screen distinguished patients with Alzheimer's disease dementia from subjective cognitive decline (AUC = 0.92), matching a standard paper-based test, while a 20-minute subset surpassed this (AUC = 0.97; p = 0.04). Test-retest reliability was very good (ICC ≥ 0.79; N = 118). OCTAL enables remote assessment for large-scale research and screening, with an open, modular architecture that makes it a uniquely sustainable and evolvable tool for the research community.

npj Digital MedicineVol. 9(1)
Hong Kong Baptist University (HK), University of Milan (IT), John Radcliffe Hospital (GB), University of Oxford (GB)
Wellcome Trust, National Institute for Health and Care Research, Medical Research Council
Openalex Percentile: Top 2%
Dementia and Cognitive Impairment Research
33.12
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Remote digital cognitive assessment for aging and dementia using the Oxford Cognitive Testing Portal OCTAL — Qian-Yuan Tang, Sijia Zhao, et al. · npj Digital Medicine (2026) | TGRS Research Map | TGRS