Cryptosporidium spp. infection drives distinct alterations in the faecal extracellular vesicles metaproteome of calves
These findings underscore that fEVs contain host and microbial proteins that are a valuable resource for studying gut physiology, pathophysiology, host-microbe-pathogen interactions, and microbiome dynamics. Changes in the proteomic profile of fEVs during Cryptosporidium spp. infection demonstrates the pathogen's ability to manipulate host immune defences and microbiome composition for its survival and replication. Overall, these findings support the utility of fEV proteomics as a non-invasive platform for biomarker discovery and advancing research in gastrointestinal health and disease in livestock.
Authors
- Mandy J. Peffers (ORCID: https://orcid.org/0000-0001-6979-0440)
- Elisabeth Dorbek-Kolin (ORCID: https://orcid.org/0000-0002-2274-4188)
- Suranga P. Kodithuwakku (ORCID: https://orcid.org/0000-0001-9491-5196)
- Kasun Godakumara
- Emily J. Clarke (ORCID: https://orcid.org/0000-0002-1174-7738)
- A Fazeli
- Chanaka Premathilaka
- Toomas Orro
Institutions
- University of Peradeniya (LK)
- University of Liverpool (GB)
- Estonian University of Life Sciences (EE)
- University of Tartu (EE)
- University of Sheffield (GB)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1186/s40104-025-01332-4
- Primary Topic
- Parasitic Infections and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Helsingin Yliopisto
- Oulun Yliopisto
- Tartu Ülikool
- Eesti Maaülikool
- Biocenter, University of Oulu