Osteoblastic cell responses to zoledronate treatment in-vitro: A systematic review
ZOL exerts direct, dose-dependent inhibitory effects on osteoblasts in-vitro, with outcomes influenced by exposure time and media composition. This review highlights the need for standardised protocols and provides quantitative guidance for modelling MRONJ and testing regenerative interventions.
Authors
- Gavin Jell (ORCID: https://orcid.org/0000-0001-8115-1609)
- Maria Florez-Martin
- Kaveh Shakib
- Adriana-Monica Radu
Institutions
- The Royal Free Hospital (GB)
- University College London (GB)
Publication Details
- Journal
- Bone
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1016/j.bone.2026.117796
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00