Gene regulatory network analysis identifies dysregulation of hypoxia pathways as contributing to glioblastoma multiforme treatment resistance in females
Our results suggest that dysregulation of hypoxia-related pathways in GBM plays a female-specific role in resistance to treatment and overall outcomes.
Authors
- Quackenbush John
- Viola Fanfani (ORCID: https://orcid.org/0000-0003-3852-6908)
- Tara Eicher (ORCID: https://orcid.org/0000-0003-1809-4458)
- Dawn L. DeMeo (ORCID: https://orcid.org/0000-0001-9653-0636)
- Katherine H. Shutta (ORCID: https://orcid.org/0000-0003-0402-3771)
- Lauren Hsu
- Derrick K. DeConti (ORCID: https://orcid.org/0000-0001-5409-1452)
- Tomisin Adebari
- Camila Lopes-Ramos
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Dana-Farber Cancer Institute (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-01-15
- DOI
- https://doi.org/10.64898/2026.01.13.26344041
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health