Single-nucleus transcriptomics reveal stress-related prefrontal activation in Tourette disorder
Together, these findings identify the DLPFC in TD as a region of heightened stress responsivity and altered excitatory-inhibitory dynamics, offering new insight into cortical mechanisms that may constrain tic suppression.
Authors
- Caterina Branca (ORCID: https://orcid.org/0000-0001-6231-2040)
- Philip Moos
- Marco Bortolato
Institutions
- University of Utah (US)
- University of Florida (US)
- Florida College (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-14
- DOI
- https://doi.org/10.64898/2026.01.14.699521
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00