Prognostic role of <scp>PET</scp> / <scp>CT</scp> volumetric parameters in paediatric Hodgkin lymphoma: A systematic review and expert recommendations from the International <scp>SEARCH</scp> for <scp>CAYAHL</scp> Group

In adults with classic Hodgkin lymphoma (cHL), metabolic tumour volume (MTV) is valuable for risk stratification. This systematic review explored the role of volumetric parameters in children, adolescents and young adults (CAYA) with cHL. This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method. Five databases were searched on 16 October 2024. Eligible studies were peer-reviewed manuscripts, written in English, published since database inception that included patients ≤21 years of age with a diagnosis of cHL treated with chemotherapy ± radiotherapy with a baseline <sup>18</sup>F-Fluorodeoxyglucose (F-FDG) PET/CT scan for MTV quantification. The search strategy identified 3669 studies, of which 35 were eligible for inclusion. Fifteen studies (43%) evaluated a cohort exclusively ≤21 years of age. All eight studies that explored the association of baseline PET parameters with known risk factors identified a significant correlation. Nine of 12 papers (75%) demonstrated a statistically significant correlation with disease response to therapy on PET/CT. Fifteen of 20 papers (75%) demonstrated an independent statistically significant correlation with clinical outcomes. In the CAYAHL population, volumetric PET parameters are valuable for risk stratification despite heterogeneity in results. Future harmonization of the segmentation approach will facilitate incorporation of MTV into clinical practice.

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Publication Details

Journal
British Journal of Haematology
Published
2026-01-14
DOI
https://doi.org/10.1111/bjh.70329
Primary Topic
Lymphoma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

Prognostic role of PET / CT volumetric parameters in paediatric Hodgkin lymphoma: A systematic review and expert recommendations from the International SEARCH for CAYAHL Group

Monica Palese, Heiko M. Schöder, Lars Kurch, Tyler Bradshaw et al.
British Journal of Haematology
Lymphoma Diagnosis and Treatment
article

Prognostic role of PET / CT volumetric parameters in paediatric Hodgkin lymphoma: A systematic review and expert recommendations from the International SEARCH for CAYAHL Group

Monica Palese, Heiko M. Schöder, Lars Kurch, Tyler Bradshaw, Jamie E. Flerlage, Jonas Steglich, Kathleen M. McCarten, Hollie Lai, Bradford S. Hoppe, Jennifer Seelisch, Sarah A. Milgrom, Christine Mauz‐Körholz, Scott Howard, Dietrich Stoevesandt, Sharon M. Castellino, Kara M. Kelly, Neeta Pandit‐Taskar, S. Claire Gowdy, Stephan D. Voss, John T. Lucas, Steve Cho, Karin Dieckmann, Egesta Lopci
article en

Abstract

In adults with classic Hodgkin lymphoma (cHL), metabolic tumour volume (MTV) is valuable for risk stratification. This systematic review explored the role of volumetric parameters in children, adolescents and young adults (CAYA) with cHL. This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method. Five databases were searched on 16 October 2024. Eligible studies were peer-reviewed manuscripts, written in English, published since database inception that included patients ≤21 years of age with a diagnosis of cHL treated with chemotherapy ± radiotherapy with a baseline <sup>18</sup>F-Fluorodeoxyglucose (F-FDG) PET/CT scan for MTV quantification. The search strategy identified 3669 studies, of which 35 were eligible for inclusion. Fifteen studies (43%) evaluated a cohort exclusively ≤21 years of age. All eight studies that explored the association of baseline PET parameters with known risk factors identified a significant correlation. Nine of 12 papers (75%) demonstrated a statistically significant correlation with disease response to therapy on PET/CT. Fifteen of 20 papers (75%) demonstrated an independent statistically significant correlation with clinical outcomes. In the CAYAHL population, volumetric PET parameters are valuable for risk stratification despite heterogeneity in results. Future harmonization of the segmentation approach will facilitate incorporation of MTV into clinical practice.

British Journal of Haematology
Western University (CA), Roswell Park Comprehensive Cancer Center (US), Children's Hospital of Orange County (US), St. Jude Children's Research Hospital (US), Memorial Sloan Kettering Cancer Center (US), University of Wisconsin–Madison (US), University of Tennessee Health Science Center (US), Justus-Liebig-Universität Gießen (DE), London Health Sciences Centre (CA), Jacksonville College (US), University of Rochester Medical Center (US), Leipzig Heart Institute (DE), Dana-Farber Cancer Institute (US), Health Insurance Review and Assessment Service (KR), University Hospital Leipzig (DE), University of Pittsburgh Medical Center (US), Mayo Clinic in Florida (US), Children's Healthcare of Atlanta (US), Children's Hospital of Western Ontario (CA), University Hospital in Halle (DE), BC Children's Hospital (CA), Resonant Sensors (United States) (US), IRCCS Humanitas Research Hospital (IT), Martin Luther University Halle-Wittenberg (DE), Medical University of Vienna (AT), University of Colorado Denver (US)
Reduced inequalities
Openalex Percentile: Top 88%
Lymphoma Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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