PTEN enhances the radiosensitivity of melanoma by inhibiting DNA-PKcs
PTEN enhances the radiosensitivity of melanoma by inhibiting the DNA-PKcs signal, weakening NHEJ repair, and delaying cell-cycle recovery. PTEN can serve as a biomarker for radiotherapy response prediction and a target for sensitization intervention, providing an experimental basis for precise radiotherapy strategies for melanoma.
Authors
- Fu Shen
- Yu Wang (ORCID: https://orcid.org/0000-0003-1562-7562)
- Shengqian Zhu (ORCID: https://orcid.org/0009-0000-4159-531X)
- Fangying Chen
- Haitao Xu
Institutions
- Second Military Medical University (CN)
- Changhai Hospital (CN)
- Ningbo University Affiliated Hospital (CN)
- Ningbo First Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-01-15
- DOI
- https://doi.org/10.3389/fcell.2025.1712429
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00