BCAR3 Hypomethylation as a Potential Diagnostic Marker for Thyroid Cancer and Its Mechanism via Promoting EMT and AKT/mTOR Pathway
<i>BCAR3</i> hypomethylation contributes to TC cells' proliferation, migration, and invasion by promoting AKT/mTOR activation and EMT. These findings highlight the potential of <i>BCAR3</i> methylation as both a biomarker and a therapeutic target in TC.
Authors
- Yifei Yin
- Yifen Zhang
- Jiacheng Yang (ORCID: https://orcid.org/0000-0002-8475-2546)
- Xuandong Huang (ORCID: https://orcid.org/0000-0001-6629-5129)
- Yizhu Mao
- Chenxia Jiang
- Rongxi Yang
- Wenkang Yu
- Yi Zhang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Xuzhou Medical College (CN)
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Second People’s Hospital of Huai’an (CN)
- Jiangsu Province Hospital (CN)
- Shanghai Municipal Center For Disease Control Prevention (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cancers
- Published
- 2026-01-15
- DOI
- https://doi.org/10.3390/cancers18020267
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00