COMPARATIVE EFFICACY AND SAFETY OF INTRAMUSCULAR MIDAZOLAM VERSUS INTRAVENOUS LORAZEPAM IN PREHOSPITAL MANAGEMENT OF STATUS EPILEPTICUS: EVIDENCE FROM RAMPART TRIAL

Background: Status Epilepticus (SE) is a life-threatening neurological emergency that requires immediate treatment. Intravenous (IV) lorazepam is a standard first-line therapy, but IV access is often delayed in Prehospital settings. Intramuscular (IM) Midazolam offers a potential alternative due to its ease of administration. Objective: To evaluate and compare the effectiveness of IM midazolam and IV lorazepam in terminating seizures in patients with status epilepticus in a Prehospital setting.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-01-16
DOI
https://doi.org/10.5281/zenodo.18255589
Primary Topic
Epilepsy research and treatment
Type
article
Field-Weighted Citation Impact
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article

COMPARATIVE EFFICACY AND SAFETY OF INTRAMUSCULAR MIDAZOLAM VERSUS INTRAVENOUS LORAZEPAM IN PREHOSPITAL MANAGEMENT OF STATUS EPILEPTICUS: EVIDENCE FROM RAMPART TRIAL

P. Priyadharshini*1, S. Lakshmi1, V. Anushree1, M. Praveenkumar2, C. Jothimanivannan3
Zenodo (CERN European Organization for Nuclear Research)
Epilepsy research and treatment
article

COMPARATIVE EFFICACY AND SAFETY OF INTRAMUSCULAR MIDAZOLAM VERSUS INTRAVENOUS LORAZEPAM IN PREHOSPITAL MANAGEMENT OF STATUS EPILEPTICUS: EVIDENCE FROM RAMPART TRIAL

P. Priyadharshini*1, S. Lakshmi1, V. Anushree1, M. Praveenkumar2, C. Jothimanivannan3
article en

Abstract

Background: Status Epilepticus (SE) is a life-threatening neurological emergency that requires immediate treatment. Intravenous (IV) lorazepam is a standard first-line therapy, but IV access is often delayed in Prehospital settings. Intramuscular (IM) Midazolam offers a potential alternative due to its ease of administration. Objective: To evaluate and compare the effectiveness of IM midazolam and IV lorazepam in terminating seizures in patients with status epilepticus in a Prehospital setting.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Openalex Percentile: Top 88%
Epilepsy research and treatment
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