Impact of Maintenance Hemodialysis on Quality of Life in the Patients of Chronic Kidney Disease

Objective: Chronic Kidney Disease (CKD) carries a major health burden in India, with hemodialysis patients facing complex therapeutic regimens and impaired quality of life (QOL). This study aimed to evaluate QOL among patients undergoing chronic hemodialysis. Methods: A cross-sectional observational study was conducted among CKD patients receiving hemodialysis at two centres in South Gujarat. Data were collected using a WHO-QOL questionnaire covering physical, psychological, social and environmental domains. Demographic and clinical variables, including comorbidities and medication use, were recorded. Statistical analysis was done using frequencies and the chi-square test. Results: Patients reported significant impairment across all QOL domains, with physical health and psychological well-being most affected. Patients with longer exposure and frequent dialysis reported higher QOL. Polypharmacy and poor medication adherence were strongly associated with lower QOL scores. Gender and addiction history did not have a significant impact on QOL. Despite regular dialysis, many patients experienced persistent fatigue, emotional distress, and social isolation. Conclusion: CKD patients on chronic dialysis in South Gujarat demonstrate markedly reduced QOL, influenced by dialysis setup, duration of therapy, dialysis frequency and drug utilization. Early detection of CKD, rational drug use, and improved access to dialysis and renal replacement therapies are essential to mitigate disease burden. Integrating QOL assessment into routine care can guide interventions to enhance patient outcomes and overall well-being.