Comparative Effectiveness of ACE Inhibitors and Angiotensin Receptor Blockers for Cardiovascular Disease Prevention in People Living with HIV and Hypertension

Our study found that both ACEIs and ARBs were effective in reducing CVD risk among PWH, with similar effectiveness observed for both medications. The analysis did not reveal statistically significant differences in effectiveness between Black and White PWH for either drug.

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Publication Details

Journal
medRxiv
Published
2026-01-15
DOI
https://doi.org/10.64898/2026.01.12.26343966
Primary Topic
HIV-related health complications and treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Comparative Effectiveness of ACE Inhibitors and Angiotensin Receptor Blockers for Cardiovascular Disease Prevention in People Living with HIV and Hypertension

Jeffrey R. Brook, GM Lucas, Henock G. Yebyo, William B. Lober et al.
medRxiv
HIV-related health complications and treatments
article

Comparative Effectiveness of ACE Inhibitors and Angiotensin Receptor Blockers for Cardiovascular Disease Prevention in People Living with HIV and Hypertension

Jeffrey R. Brook, GM Lucas, Henock G. Yebyo, William B. Lober, Maile Karris, Tom Forzy, Keri N Althoff, Michael A Horberg, Timothy R Sterling, Michael Silverberg, Sonia Napravnik, Vincent C. Marconi
article en

Abstract

Our study found that both ACEIs and ARBs were effective in reducing CVD risk among PWH, with similar effectiveness observed for both medications. The analysis did not reveal statistically significant differences in effectiveness between Black and White PWH for either drug.

medRxiv
University of North Carolina at Chapel Hill (US), Kaiser Permanente (US), Johns Hopkins University (US), Emory University (US), University of Zurich (CH), Johns Hopkins Medicine (US), University of California System (US), University of California San Diego (US), University Hospital of Zurich (CH), Vanderbilt University Medical Center (US)
National Science Foundation, Government of Alberta, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, National Institutes of Health, Centers for Disease Control and Prevention, Health Resources and Services Administration, Agency for Healthcare Research and Quality, Canadian Institutes of Health Research, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Human Genome Research Institute, National Cancer Institute, National Institute on Deafness and Other Communication Disorders, National Institute of Nursing Research, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Dental and Craniofacial Research
Good health and well-being
Openalex Percentile: Top 89%
HIV-related health complications and treatments
DOIOpen Access PDFOpenAlex
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