Validation of serum hypersensitive thyroglobulin assay in alternative fine needle aspiration matrix

Analytical validation of the ultrasensitive immunoassay for FNA samples was obtained for 3 matrices; matrix features and sample storage at ‒20 °C do not affect the reliability of thyroglobulin measurements. Use of a protein matrix is recommended for possible presence of samples with low analyte values.

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Publication Details

Journal
Laboratory Medicine
Published
2025-11-24
DOI
https://doi.org/10.1093/labmed/lmaf087
Primary Topic
Thyroid Cancer Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Validation of serum hypersensitive thyroglobulin assay in alternative fine needle aspiration matrix

Patrizia Agretti, Donatella Taddei, Chiara Nencetti, Lea Bianchi et al.
Laboratory Medicine
Thyroid Cancer Diagnosis and Treatment
article

Validation of serum hypersensitive thyroglobulin assay in alternative fine needle aspiration matrix

Patrizia Agretti, Donatella Taddei, Chiara Nencetti, Lea Bianchi, Maria Rita Sessa
article en

Abstract

Analytical validation of the ultrasensitive immunoassay for FNA samples was obtained for 3 matrices; matrix features and sample storage at ‒20 °C do not affect the reliability of thyroglobulin measurements. Use of a protein matrix is recommended for possible presence of samples with low analyte values.

Laboratory MedicineVol. 57(1)
University of Pisa (IT), Azienda Ospedaliera Universitaria Pisana (IT)
Openalex Percentile: Top 27%
Thyroid Cancer Diagnosis and Treatment
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