Parabacteroides distinguishes bipolar disorder from schizophrenia: toward a microbial biomarker for differential diagnosis

These findings suggest that Parabacteroides, particularly <i>Parabacteroides_B_862066</i>, may serve as a microbial indicator differentiating SCZ from BD. The distinct microbial and functional profiles observed between the two disorders highlight potential microbiota-related mechanisms underlying psychiatric heterogeneity and may provide insights into subtype-specific pathophysiology.