Lugol’s solution for preoperative management of a TSH/GH-secreting pituitary adenoma with suboptimal response to octreotide: a case report
This case highlights Lugol's solution as a rescue therapy for SSA-insensitive TSH/GH co-secreting pituitary adenomas. Despite SSTR2/5 positivity, suboptimal response to octreotide suggests tumor heterogeneity or downstream signaling defects. Preoperative Lugol's solution should be considered when SSAs and methimazole fail.
Authors
- Xiaotian Lei (ORCID: https://orcid.org/0000-0001-5741-0607)
- Liu Chen (ORCID: https://orcid.org/0000-0003-0966-2804)
- Guiliang Peng (ORCID: https://orcid.org/0000-0002-0829-0079)
- Long Min
- Feng Wu
- Weiling Leng
Institutions
- Army Medical University (CN)
- Southwest Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-01-15
- DOI
- https://doi.org/10.3389/fendo.2025.1698948
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00