Hematoprotective Properties of Polyherbal Formulation on Streptozocin-Induced Diabetic Wistar Rats

To treat type 2 diabetes mellitus, the study focuses on polyherbal anti-diabetic extracts from several plants, administered at varying dosages. Ayurvedic medicines are widely accepted due to their efficacy, safety, affordability, ubiquity, and acceptance. Because polyherbal medicines contain glycosides, alkaloids, flavonoids, and other compounds with diverse modes of action, they have long been used to treat diabetes worldwide. This study examined the Antidiabetic and haematological effects of a polyherbal formulation (PHF) in streptozotocin (STZ)- induced diabetic rats. Objective: To examine the antidiabetic effects of Polyherbal formulation on haematological parameters in streptozotocin-induced diabetic rats. Method: In this study, Wistar albino rats (n=6) were split up into five groups. Streptozotocin was injected intraperitoneally to male Wistar rats to cause diabetes. After being confirmed diabetic, animals were treated orally with distilled water or extracts at 200 or 400 mg/kg body weight daily for 30 days. Results: Blood glucose levels were significantly reduced by the extract, with the greatest reduction observed at 400 mg/kg body weight. After extract administration at both doses, the quantities of red blood cells, white blood cells, and their functional indices all increased considerably. Also, in diabetic rats, water and feed consumption were intensely decreased, and weight loss was minimised at both dosages. Keywords: Diabetis, Polyherbal formulation, Streptozotocin, Wistar Albino Rats, Haematological parameters