Beyond eosinophils: A proteomic dissection of remodeling and inflammation in suspected eosinophilic esophagitis
High-throughput proteomic profiling revealed distinct biomarker signatures in EoE. CCL26 was the most significantly upregulated marker, associated with both eosinophilic inflammation and epithelial remodeling. COL9A1 may be associated with GERD-related inflammation and PPI responsiveness. These findings support a dual-pathway model of EoE and suggest potential for biomarker-guided diagnosis and treatment.
Authors
- Netanel Agajany (ORCID: https://orcid.org/0000-0002-1577-4338)
- Vered Richter (ORCID: https://orcid.org/0000-0001-6003-9220)
- Dani Cohen (ORCID: https://orcid.org/0000-0003-2664-2303)
- Tzippora Shalem
- Haim Shirin
- Efrat Broide
- Adi Eindor‐Abarbanel
- Nimrod Moss‐ Ophir
Institutions
- Tel Aviv University (IL)
- Assaf Harofeh Medical Center (IL)
Publication Details
- Journal
- Journal of Pediatric Gastroenterology and Nutrition
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1002/jpn3.70347
- Primary Topic
- Eosinophilic Esophagitis
- Type
- article
- Field-Weighted Citation Impact
- 0.00