Activating KRAS mutations mark premalignant cystic structures in congenital pulmonary airway malformations
KRAS<sup>POS</sup> cyst organoids show transcriptomic similarities with KRAS mutated lung cancers, show changes in cellular composition and have increased growth and proliferation. These findings support the hypothesis that KRAS mutated CPAM cysts belong to a group of CPAM patients at higher risk of developing a malignancy.
Authors
- Marjon Buscop-van Kempen
- Marco J. Schnater
- Floor Benthem
- Anne Boerema-de Munck
- Rene M. H. Wijnen (ORCID: https://orcid.org/0000-0001-7266-9713)
- Robbert J. Rottier (ORCID: https://orcid.org/0000-0002-9291-4971)
- Cathy van Horik (ORCID: https://orcid.org/0000-0003-2585-1197)
- Wilfred F. J. van IJcken (ORCID: https://orcid.org/0000-0002-0421-8301)
Institutions
- Erasmus MC (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Respiratory Research
- Published
- 2026-01-15
- DOI
- https://doi.org/10.1186/s12931-025-03491-4
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00