Activation of <scp>TGR5</scp> Alleviates Renal Fibrosis by Promoting <scp>NEDD4L</scp> ‐Mediated p‐Smad2/3 Ubiquitination
TGR5 activation protects against renal fibrosis by inhibiting the PI3K-SGK1-NEDD4L axis and promoting p-Smad2/3 degradation.
Authors
- Lihe Lu (ORCID: https://orcid.org/0000-0003-4518-3325)
- Liwen Xu (ORCID: https://orcid.org/0000-0003-2133-8257)
- Suchun Li (ORCID: https://orcid.org/0000-0002-5748-681X)
- Chunling Li (ORCID: https://orcid.org/0000-0002-5633-7353)
- M. Wang (ORCID: https://orcid.org/0000-0002-4713-9646)
- X. Zhao (ORCID: https://orcid.org/0009-0008-6024-7722)
- Xi Yuan
- Luosha Long
- Xinyan Wu
- Jinyi Lin
- Ruiqi Bai
- Meng Li
- Weidong Wang
- Wei Chen
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- University College London (GB)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2026-01-14
- DOI
- https://doi.org/10.1111/apha.70163
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Natural Science Foundation of Guangdong Province