Development of an anti-rat complement C2 antibody that improves renal outcome in a rat kidney transplant model
Our study shows the successful development of an analogue of empasiprubart that can be used in preclinical <i>in vivo</i> disease models and highlights the potential of C2-blocking as a therapeutic strategy for preventing delayed graft function following kidney transplantation.
Authors
- Tim Delahaye
- Yasmine Driege (ORCID: https://orcid.org/0000-0003-3545-4283)
- Eline Haspeslagh (ORCID: https://orcid.org/0000-0002-1053-428X)
- Jolien Delaere (ORCID: https://orcid.org/0009-0004-6628-3469)
- Inge Van de Walle (ORCID: https://orcid.org/0000-0002-7631-399X)
- Laura Bracke
- Karen De Winter
- Raphael Bilgraer
- C. Erik Hack
Institutions
- Argenx (Belgium) (BE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1668376
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Argenx